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Kynurenine formylase

Kynurenine Formylase. Hydrolysis of formylkynurenine to kynurenine is catalyzed in liver preparations by an enzyme (formylase or kynurenine formamidase) with rather low specificity for aromatic formamides. The reaction with formylkynurenine, however, is faster than that with any analogs. A very similar enzyme has been obtained from Neurospora. In contrast, an enzyme from insects does not hydrolyze formylanthranilic acid, a model substrate for formylase from other sources, or other analo-... [Pg.351]

The tryptophan-oxidizing activity can be assayed by various determinations of the substrate, but more rapid and convenient assays have been used based on the appearance of the product. The initial product of tryptophan oxidation is A -formylkynurenine, but this is rapidly hydrolyzed by an enzyme, kynurenine formylase (Mehler and Knox, 1951) or formamidase, that is much more active than tryptophan pyrrolase. The kynurenine that is produced in the second reaction accumulates... [Pg.108]

See other pages where Kynurenine formylase is mentioned: [Pg.138]    [Pg.138]    [Pg.138]    [Pg.138]    [Pg.83]    [Pg.100]    [Pg.109]   
See also in sourсe #XX -- [ Pg.257 , Pg.258 ]

See also in sourсe #XX -- [ Pg.351 ]

See also in sourсe #XX -- [ Pg.138 ]

See also in sourсe #XX -- [ Pg.108 ]



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