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KvAP channel

Shrivastava IH, Durell SR, Guy FIR (2004) A model of voltage gating developed using the Kvap channel crystal structure. Biophys J 87 2255-2270... [Pg.70]

Fig. 12.5 Key elements of hERG channel topology are schematically illustrated using one subunit of the X-ray structure of bacterial KvAP [17], A hERG blocker is represented according to published evidence [1 7]. The... Fig. 12.5 Key elements of hERG channel topology are schematically illustrated using one subunit of the X-ray structure of bacterial KvAP [17], A hERG blocker is represented according to published evidence [1 7]. The...
Monticelli, L., Robertson, K.M., MacCallum, J.L., Tieleman, D.P. Computer simulation of the KvAP voltage-gated potassium channel steered molecular dynamics of the voltage sensor. FEBS Lett. 2004, 564, 325-32. [Pg.20]

The voltage sensor domain is also significant for creating a more complete model of the hERG channel. However, this domain does not directly interact with the compounds. This domain may be modeled based on the structures of the isolated voltage sensor from KvAP [109,131] and the structure of the transmembrane domain of Kvl.2 [82,132],... [Pg.454]

Lee SY, Lee A, Chen J, MacKinnon R (2005) Structure of the KvAP voltage-dependent K -I- channel and its dependence on the lipid membrane. Proc Natl Acad Sci USA 102 15441-15446... [Pg.173]

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