Kochi reaction

A complementary method is the Kochi reaction. This reaction is especially useful for the generation of secondary and tertiary alkyl chlorides through decarboxylation of carboxylic acids, where the classical method may not work. As reagents, lead tetraacetate and lithium chloride are then employed ... 

Alkyl fluorides have been generated from the reaction of carboxylic acids with one equivalent of xenon difluoride in dichloromethane or chloroform solution. The process has been named fluorodecarboxylation", the fluorine analog of the Hunsdieckerand Kochi reaction.8384 Both primary and tertiary acids react very well, but secondary acids react less readily. A possible scheme involves a free-radical mechanism including an unstable fluoroxenon ester of an appropriate acid.84... 

The Kochi Reaction is a one-carbon oxidative degradation of carboxylic acids, and is a valuable alternative to the Hunsdiecker Reaction. A Pb(IV) reagent is the oxidant, and this reaction is suitable for synthesis of secondary and tertiary chlorides. 

Stolow and Giants have examined the stereochemistry of the Kochi reaction. Both fir- and trnn.s-4-t-butylcyclohexanecarboxylic acid (8) and (9) give the same product... 

The Kochi reaction has also been used to demonstrate polar effects of remote substituents upon free-radical stereoselectivities in chlorine atom transfer. ... 

Kochi reaction. Synthesis of organic chlorides by decarboxylation of carboxylic acids in the presence of lead tetraacetate and lithium chloride. 

Other references related to the Kochi reaction are cited in the literature. ... 

Koch-Haaf Carboxylations Kochi Reaction Koenigs-Knorr Synthesis Kolbe Electrolytic Synthesis Kolbe-Schmitt Reaction Komer-Contardi Reaction Kostanecki Acylation Krafft Degradation Krapcho Decarbalkoxylation... 

Kjeldahl test Kochi reaction kopsine kryptonates... 

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