Kinetics of drug action

MacKay, D. (1977). A critical survey of receptor theories of drag action. In Kinetics of drug action, edited by J. M. Van Rossum, pp. 255—322. Springer-Verlag, Berlin. 

M. Danhof, M. Hisaoka, and G. Levy, "Kinetics of drug action in disease states. II. Effect of experimental renal dysfunction on phenobarbital concentrations in rats at onset of loss of righting reflex," J. Pharmacd. Exp. Ther., 230 627-631 (1984). 

M. Danhof, M. Hisaoka, and G. Levy, "Kinetics of drug action in disease... 

Paalzow, L.K. Paalzow, G.H.M. Tfelt-Hansen, P. Kinetics of drug action. In Pharmacokinetics. A Modern View, Benet, L.Z., Levy, G., Ferraiolo, B.L., Eds. Plenum Press New York, 1984 315-343. 

As an example of establishing a concentration-response relationship in Phase 2 studies, Pillai and his colleagues utilized a kinetics of drug action model and simulation to recommend a novel intermittent oral and rv ibandronate regimen for the treatment of osteoporosis. The model characterized the relationship between an ibandronate dose and the change of pCTX, a sensitive biomarker of bone turnover, as a PD response, and adequately described the time-course of pCTX change. In that paper, utility of biomarkers was demonstrated when clinical outcome is slow to come. ° ... 

Levy, G., Kinetics of drug action in man, Acta Pharmacol. Toxicol. Copenh., 29 (Suppl. 3) 203-210, 1971. 

Hill-Langmuir equation and the application of the law of mass action to the kinetics of drug-receptor interaction ... 

Van Boxtel CJ, Holford NHG, Danhof M, editors. The in vivo study of drug action. Principles and applications of kinetic-dynamic modelling. Amsterdam Elsevier 1992. 

Mass action kinetics of drug-receptor binding... 

Interspecies pharmacokinetic scaling, biological design and neoteny. 19. 139 A Kinetic approach to the mechanism of drug action. 3. 57 Laboratory models of atherosclerosis. 9, 41... 

This is the name given to the study of the kinetics of drug absorption, distribution, metabolism, and excretion, all of which are rate-controlled. The earliest studies, which were concerned with inhaled anaesthetics (Widmark, 1920 Dominguez, 1933), were not suited for general application. The fundamental equations were introduced by T. Teorell (1937) in his studies of insulin action. He provided simple kinetic formulae to monitor the concentration of... 

The basic kinetic concepts in the body system initially came from the study of drug actions, or pharmacokinetics. Nowadays, these principles are usually apphed to study or predict the movement of a substance in the organism, such as a toxin, an environmental pollutant, or even a phytochemical, constituting what is called biokinetics. 

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