Kinetic Models for Microbial Product Formation

Zeng AP (1995), A kinetic model for product formation of microbial and mammalian cells, Biotechnol. Bioeng, 46 314-324. 

Microbial activities like growth and product formations can be regarded as a sequence of enzymatic reactions. On this basis Ferret (1960) constructed a kinetic model for a growing bacterial cell population. The main pathways for major nutrients are considered together with pathways for minor nutrients and trace elements linked to each other. This metabolic network can be simplified with the aid of the concept of the rate-determining step (rds), resulting in a master reaction or bottleneck that limits the total flux and the rate of the process. 

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