Kidney transplantation delayed graft function

There are four potential clinical presentations for acute CSA nephrotoxicity asymptomatic increases in serum creatinine (SCr) without overt renal dysfunction, acute kidney injury, delayed graft function after renal transplantation and recurrent or de novo hemolytic uremic syndrome (Table 2). 

Perico N, Cattaneo D, Sayegh MH, Remuzzi G. Delayed graft function in kidney transplantation. Lancet 2004 364 1814-1827. 

Increase in TAC is not always a good prognostic it may simply indicate an initial response to oxidative stress, as with concentrations of individual antioxidants and activities of antioxidant enzymes, or when it is due to disturbances in uric acid metabolism. Because uric acid is the main determinant of TAC of blood plasma, TAC increases in situations when the concentration of urate is increased, for example, in metabolic disorders and kidney failure. TAC is increased in urine from renal transplant recipients with delayed graft function (SI6). Ischemia of small intestine leads to an increase in TAC of rat blood serum, which is maximal (almost twofold) immediately after termination of 45-min ischemia (S22). TAC of blood plasma of rats poisoned with a high dose of carbon tetrachloride (1200 mg/kg, intraperitoneal injection, measurement 16 hr after injection) was significantly (over twofold) increased (Kl). These apparently paradoxical effects can be explained, however, by release of antioxidants from cells undergoing necrosis. Increase in TAC after intensive physical exercise also may be a marker of tissue... 

Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, Edelstein CL, Devarajan P. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant 2006 7 1639-1645. 

Craved P, Codreanu , Satta A, Turturro M, Sghirlanzoni M, Remuzzi G, Ruggenenti P. Cyclosporine prolongs delayed graft function in kidney transplantation are rabbit anti-human thymocyte globulins the answer Nephron Clin Pract 2005 101 c65-71. 

Vilalta R, Lara E, Madrid A, Chocron S, Vazquez A, Casquero A, Nieto J. Delayed graft function is reduced with antithymocyte globulin induction in pediatric kidney transplantation. Transplant Proc 2009 41 (6) 2373-5. 

Maestri M, Dafoe DC, Adams GA,Gaspari A, Luzzana F, Innocente F, Rademacher J, Dionigi P, Barbieri A, Zonta F,Zonta A, Rabkin R. Insulin-like growth factor-1 ameliorates delayed kidney graft function and the acute nephrotoxic effects ofcyclosporine. Transplantation 1997 64 185-190. 

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