Ketamine statistics

The a and b waves are always observed and measured with white light. With the blue light, the a wave cannot be measured but the b wave is present. When we compare the results, we do not see any statistical difference between dogs anesthetized by ketamine-diazepam and dogs anesthetized with medetomidine.The amplitude of a and b waves was very variable and this variation is probably related to several factors age, breed... but mainly to an insufficient standardization of dark adaptation. We should respect more strictly twenty minutes of dark adaptation in a future experiment. This factor is known to influence die amplitude of a and b waves. 

For statistical analysis, the latencies measured on conscious dogs were averaged for each eye in order to obtain the same number of data points as for the ketamine and thiopental anesthetic trials. Statistical analysis was performed using the Fischer test. 

The Fisher test showed statistically significant differences in "a" wave latencies between conscious and ketamine anesthetized animals and in "b wave latencies between conscious and ketamine and thiopental anesthetized animals Although differences only... 

A randomised double-blind placebo-controlled trial [33 ] investigating ketamine in the management of cancer pain demonstrated no improvement with escalating doses of ketamine (100, 300 and 500 mg) delivered subcutaneously over 24 h. There was, however, a statistically significant increase in adverse events in the ketamine group. This included cognitive disturbances, dizziness, site irritation, somnolence and nausea. 

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