Ketamine history

Ketamine is often taken with other drugs, such as cocaine, marijuana, alcohol, and Ecstasy, which greatly increases the risk for overdose. Ketamine tends to be taken by people with a history of experimenting with numerous other drugs. Ketamine is also occasionally taken by physicians and veterinarians, who have easy access to the drug and want to experiment with its psychedelic effects. 

The non-FDA-approved indications are discussed below. One of the most encountered clinical scenarios is the use of ketamine as an analgesic for sedation (gastroenterological procedures, biopsies, painful emergency room procedures, burn dressing changes, lumbar punctures, etc.), especially in patients with a history of bronchospasm. It is frequently used as an adjunct to local anesthesia alone, or with the use of propofol and midazolam. 

The radiological findings of this adverse reaction have been described in 23 patients, all with a history of ketamine abuse, who had severe lower urinary tract symptoms /62 7-... 

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