Keratinocytes gangliosides

Paller, A.S., Arnsmeier, S.L., Robinson, J.K., and Bremer, E.G. Alteration in keratinocyte ganglioside content in basal cell carcinomas. J. Invest. Dermatol (1992) 98, 226-232. 

Although glucosylceramides are the predominant epidermal glycosphingolipids,8 various classes of glycosphingolipids such as acylglucosylceramides and gangliosides have been identified in epidermis and cultured keratinocytes. 

Not only biochemical analysis, but immunohistochemical staining with antibodies against gangliosides has similarly revealed the existence and distribution of gangliosides in epidermis. Nakakuma et al. showed that epidermal keratinocytes reacted with an anti-GM3 monoclonal antibody, but not an anti-GD3 mAb.11 Expression of GM3, predominantly in the stratum corneum, was reported by Paller et al.12 In contrast, Hersey et al. detected GD2 in the basal and spinous layers of the epidermis, whereas neither GM3 nor GD3 was detected in normal skin.13 However, the epidermis adjacent to naevi and primary melanoma strongly expressed GD3.13... 

Seishima, M., Takagi, H., Okano, Y., Mori, S., and Nozawa, Y., Ganglioside-induced terminal differentiation of human keratinocytes early biochemical events in signal transduction, Arch. Dermatol. Res., 285, 397, 1993. 

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