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Keppra - Levetiracetam

Levetiracetam (Keppra). Levetiracetam has been successful in treating partial seizures in adults when used in conjunction with traditional antiseizure drugs. This drug does not appear to decrease seizure activity via one of the common antiseizure mechanisms (stabilize sodium channels, increase GABA inhibition, and so forth), and the mechanism of this drug is therefore unknown. Levetiracetam is usually well tolerated, although some patients may experience sedation, dizziness, and generalized weakness. [Pg.111]

Gabapentin (Neurontin) Lamotrigine (Lamictal) Levetiracetam (Keppra) Lorazepam (Ativan, others)... [Pg.42]

Levetiracetam (Keppra) has recently been approved for the treatment of partial-onset seizures. It appears to be safe and effective its exact therapeutic profile has yet to be determined. It does not appear to share any of the mechanisms of action of agents that have been discussed to this point. It does have a highly specific brain binding site, but the significance of this observation to its mechanism of action has not been elucidated. [Pg.382]

Levetiracetam Keppra Treatment adjunct in partial onset seizures in adults... [Pg.110]

Barrueto F Jr, Williams K, Howland MA, Hoffman RS, Nelson LS. A case of levetiracetam (Keppra) poisoning with clinical and toxicokinetic data. J Toxicol CUn Toxicol 2002 40(7) 881-4. [Pg.2037]

Levetiracetam (Keppra) is approved for adjunctive therapy and treatment of partial onset seizures in adults with epilepsy. Levetiracetam is 100% bioavaflable. Once absorbed, it is <10% bound to protein and has a volume of distribution of 1.0 L/kg. Following an oral dose, it reaches maximum... [Pg.1250]

Levetiracetam (Keppra) SorP (Hep or EDTA) Therap pg/mL 5.88 pmol/L... [Pg.2309]

Levetiracetam is the active ingredient of Keppra approved for the treatment of epilepsy. The key step of the current manufacturing route involves resolution of a racemic 2-aminoamide by L-tartaric acid to provide the desired (S)-aminoamide, the penultimate precursor to levetiracetam (Scheme 8.14) [63, 64], This approach involves many green chemistry issues as a result of poor resolution and cyclization yields (35 and 56%, respectively). [Pg.248]

See other pages where Keppra - Levetiracetam is mentioned: [Pg.264]    [Pg.264]    [Pg.606]    [Pg.204]    [Pg.223]    [Pg.532]    [Pg.580]    [Pg.97]    [Pg.593]    [Pg.660]    [Pg.272]    [Pg.1036]    [Pg.386]    [Pg.386]    [Pg.331]    [Pg.785]    [Pg.512]    [Pg.998]    [Pg.1576]   


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Levetiracetam

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