Kendall, Edward

Kendall, Edward Calvin (1886-1972) American Biochemist Edward Calvin Kendall was born on March 8, 1886, in South Norwalk, Connecticut. He was educated at Columbia University and obtained a bachelor of science degree in 1908, a master s degree in chemistry in 1909, and a Ph.D. in chemistry in 1910. 

Kendall, Edward Calvin (1886-1972) U.S. biochemist who studied the hormones produced by the outer zone (cortex) of the adrenal gland and, from his findings, synthesized cortisone. This led to the valuable range of corticosteroid drugs. In 1950, Kendall and his colleague, Philip Hench, were awarded the Nobel Prize in physiology or medicine. 

Phillip S. Hench, Edward C. Kendall, and Tadeus Reichstein Physiology/Medicine ACTH... 

Hydroxycorticosterone)] (glucocorticoid, steroid) Tadeusz Reichstein (Poland/Switzerland) Edward Kendall Philip Hench (USA) Nobel Prize, Physiology/Medicine, 1950, glucocorticoids) [Cortisone (= 17-Hydroxy-11 -dehydrocorticosterone)] (glucocorticoid, steroid)... 

Animals 11-Dehydrocortisol Cortisone isolated by Edward Kendall (USA, Nobel Prize, Physiology/Medicine, with T. Reichstein P. Hench) synthesized (1951) by Robert Burns Woodward (USA, chemist Nobel Prize, 1965)... 

Edward Calvin Kendall, Tadeus Reichstein, Philip Showalter Hench Hormones of the adrenal cortex, their structure and biological effects... 

Cortisone is a steroid produced in the adrenal glands of the human body. The isolation of cortisone from the mixture of molecules produced in these glands was carried out by American biochemist Edward Kendall and coworkers. Kendall shared the Nobel Prize in physiology or medicine for this work in which he also helped establish the usefulness of cortisone in the treatment of arthritis. 

Edward Kendall recognized that symptoms of one type of arthritis decrease in females during pregnancy. He worked... 

Kendall, A. I., and Edwards, M. R., 1911. A method for determining the germicidal value and penetrating power of liquid disinfectants. Jour, of Infectious Diseases, 8, 250-57. 

If insulin revolutionized diabetes mellitus treatment, cortisone discovery was another revolution in inflammatory and arthritis management. The discovery of corticosteroids as a therapeutic can be linked to Thomas Addison (1793-1860), who made the connection between the adrenal glands and the rare Addison s disease in 1855.Edward C, Kendall (1886-1972) at the Mayo Clinic (Rochester, USA) and Tadeus Reichstein (1897 -1996) at the University of Basel (Switzerland) independently isolated several hormones from the adrenal cortex. In 1948, Kendall and Philip S. Hench (1896-1965) demonstrated the successful treatment of patients with rheumatoid arthritis using cortisone. Kendall, Reichstein, and Hench were awarded the 1950 Nobel Prize in Physiology or Medicine for determining the structure and biological effects of adrenal cortex hormones. 

The first pure hormone to be isolated from an endocrine gland was epinephrine, which led to further molecular modifications in the area of sympathomimetic amines. Subsequently, norepinephrine was identified from sympathetic nerves. The development of chromatographic techniques allowed the isolation and characterization of a multitude of hormones from a single gland. In 1914, biochemist Edward Kendall isolated thyroxine (T ) from the thyroid gland. He subsequently won... 

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