Kelvin nanosuspensions

Nanosuspensions have wide applications in various industrial fields, among which can be included drug delivery systems of poorly soluble compounds, whereby reducing the particle size to nanoscale dimensions enhances drug bioavailabiUty. This is due to the increase in solubility of the active ingredient on reduction of the particle radius, as given by the Kelvin equation [2] ... 

Unlike ordinary suspensions with particle sizes down to a few xm, nanosuspensions deserve attention not only for the enormous increase of the specific surface area, which brings about a high dissolution rate upon dilution. Moreover, the extremely small particles have a solubility exceeding the common solubility Cs in equilibrium with macroscopic particles. As the diameter of particles falls below 1 fji,m, the solubility increases with shrinking particle size (although normally perceived as a substance characteristic, for a given solvent composition being dependent only on temperature) as described by the Kelvin equation ... 

Many water insoluble drugs are formulated as nanodispersions, namely nanoemulsions and nanosuspensions. These systems enhance the bioavailability of insoluble drugs, whereby reducing the droplet or particle size to nanoscale dimensions increases the solubility of the drug. This can be clearly understood if one considers the effect of size on solubility as given by the Kelvin equation [10]... 

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