Kaolin-pectin drug interactions

Drugs that may interact with lincosamides include erythromycin, kaolin-pectin, and neuromuscular blockers (nondepolarizing). 

Albert KS, DeSante KA, Welch RD, DiSanto AR. Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin. J Pharm Sci 1978 67 1579-1582. 

Drug Interactions - Absorption half-life of the antibiotic, clindamycin, was prolonged in human subjects when a kaolin-pectin antidiarrheal suspension was coadministered, although the extent of absorption remained the same. On the other hand, both the rate and the extent of absorption of digoxin were lower when it was coadministered with the same kaolin-pectin suspension. Physical absorption and alterations in gut transit time appeared to partly explain the findings. 

Healthy subjects were given tetracycline 250 mg as a solution or as a capsule, with and without 30 rtiL of kaolin-pectin (Kaopectate). The absorption of both formulations was reduced by about 50% by the kaolin-pectin. Even when the kaolin-pectin was given 2 hours before or after the tetracycline, the drug absorption was still reduced by about 20%. The likely reason for this interaction is that tetracycline becomes adsorbed onto the kaolin-pectin so that less is available for absorption. 

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