Kallikreins mutations

Sequence changes, including polymorphisms and mutations, are clinically important. In addition to medicolegal applications, they can also be indicators for susceptibility and prognosis for different malignancies [52]. KLK3 is the most extensively studied kallikrein in this respect. Comparison of the... 

In general, the examination of sequence variation within the 300-kb kalli-krein locus has not been performed in detail, and it is therefore possible that inactivating mutations within the coding region of kallikrein genes exist but await discovery. Kallikrein gene inactivation in human diseases would likely provide clues for the physiological functions of these diseases. 

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