Kainate receptors cerebellum

Regional distribution studies indicate that the highest density of kainate receptor occurs in the stratum lucidum of the hippocampus (mossy fiber system) and in the inner and outer layers of the neocortex. The highest density of NMDA receptors is found in the hippocampus, stratum radiatum, and in the striatum, thalamus, and cerebral cortex. The distribution of AMPA receptors is similar to that of NMDA receptors, but in the cerebellum AMPA receptors predominate in the molecular layer... 

Porter RH, Eastwood SL, Harrison PJ. 1997. Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. Brain Res 751 217-231. 

Fig. 19. The cell types in the adult rat cerebellum and their expression of the AMPA, NMDA and kainate receptor subunit mRNAs [circuit diagram adapted from Bahn and Wisden (1997) Cull-Candy et al. (1998)]. Excitatory terminals are open circles marked Inhibitory terminals are filled triangles marked and their cells are marked GAD (glutamic acid decarboxylase).

R16. Roberts, P. J., Foster, G. A., and Thomas, E. M., Neurotoxic action of methyltetrahy-drofolate in rat cerebellum unrelated to direct activation of kainate receptors. Nature (London) 293, 654-655 (1981). 

Fig. 50. Distribution of GluR5 (A), GluR6 (B), GluR7 (C), KA-1 (D), KA-2 (E) of subunits in RNAs of high-affinity kainate receptor mRNAs in coronal sections at level of the cerebellum of the rat. Gr, granular layer LC, locus coeruleus Mol, molecular layer P, Purkinje cell layer Po, pontine nuclei. Scale bars 2.3 mm. Wisden and Seeburg (1993).

Gregor, P., Eshhar, N., Ortega, A., and Teichberg, V. (1988). Isolation, immunochemical characterization and localization of the kainate subclass of glutamate receptor from chick cerebellum. EMBO J. 7, 2673-2679. 

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