K role of water dynamics

As discussed in Chapter 8, many proteins seem to undergo a glass transition around 200 K [10]. Experiments and simulations also show that below this temperature, the dynamic behavior of proteins changes from anharmonic to harmonic 

The proximity of this liquid-liquid transition to the protein-glass transition temperature is suggestive. Clearly, at temperatures below 220 K or so, the dynamics of water and protein are highly coupled. A recent computer simulation study has shown that the stmctural relaxation of protein requires relaxation of the water HB network and translational displacement of interfacial water molecules. It is, therefore, clear that the dynamics of water at the interface can play an important role. This is an interesting problem that deserves further investigation. 

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Protein-glass transition at 200 K role of water dynamics... 

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