Jaundice Pathogenesis

Verdin icterus is deemed to be the prototyp>e of obstructive jaundice, particularly in long-standing courses of the disease melas icterus displays a greyish green hue rubin icterus (rust-coloured) is mainly seen as a sign of hepatocellular jaundice, whereas flavine icterus is more likely to occur in cases of haemolysis (Th. Brugsch, 1930). Such systematization of the icteric forms in terms of pathogenesis is unreliable and obsolete, since the differences in colour mainly correlate with the duration of the jaundice and the level of serum bilirubin. 

Special forms There are a multitude of factors involved in the pathogenesis of intrahepatic benign postoperative jaundice hypoxia, hypotension, haemolysis, toxins, sepsis and medicaments are just a few of them. (5, 6, 14, 18, 23) Likewise, jaundice in intensive-care patients (2, 7, 15) as well as after long-term total parenteral nutrition belong to this category, (l, 4)... 

The major clinical manifestation of AAT deficiency is emphysema, which tends to occur at an earlier age and can occur in the absence of smoking. It is estimated that 1% of emphysema is related to AAT deficiency. In neonates, AAT deficiency is often associated with hepatitis in one study, almost one third of infants with prolonged jaundice were found to be AAT deficient. About 20% of AAT deficient infants develop hepatitis, with up to 25% 1-year mortality. In those who survive the first year, however, evidence of liver injury diminishes and usually resolves by age 12. At age 18, none of 183 individuals with AAT deficiency had clinical evidence of liver disease, none had elevated procollagen III peptide, and less than 20% had elevated liver-associated enzymes. These findings suggest that AAT may have minimal effects on pathogenesis of liver disease in adults." ... 

Severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency pathogenesis and global epidemiology. 

A third form of congenital jaundice differs from the preceding one in that the bilirubin that accumulates in the blood is the direct type. Again, the pathogenesis of that disease is not know, but it cannot result from interference with the transferase system since bilirubin... 

It has long been known that copper toxicity leads to haemolytic jaundice in sheep [88]. The pathogenesis has been... 

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