Jalap resin

Physiological Effects.—Jalap resin is a local Irritant. It actB as a powerful and drastic purgative. To scammony it is closely allied, not only by its effects, but ulso by botanical affinities and chemical proparties. It is much Icsb irritant to the intestinal mucous membrane than gamboge and, therefore, Is a much safer purgative. 

Octalactone Jalap resin Saccharomyces cere-visiae Coconut... 

E. Votoek and F. Valentin, Rhamnoconvolvulic acid, Collect. Czech. Chem. Comm., 1 (1929) 47-54. F. B. Power and H. Rogerson, Chemical examination of the root of Ipomoea orizabensis, J. Chem. Soc., 101 (1912) 1-26. L. A. Davies and R. Adams, Structures of convolvulinolic and jalapinolic acids. Synthesis of 11-hydroxypentadecanoic and 11-hydroxyhexadecanoic acids, J. Am. Chem. Soc., 50 (1928) 1749-1755. C. Mannich and P. Schumann, Jalap resin and its principal constituents, convolvulin, Arch. Pharm., 276 (1938) 211-226. 

Occurs in jalap resin and in Spomoca and Scammory resins. Cryst. (EtOAc). Mp 68-69 . [a]o +0.79 (CHCI3). 

Operculina mac- Tuber (Jalapae Brazilian jalap resin EISP Major GA tham- EISP glu, rha EISP aca, pra. Mannich and... 

Fig. 8.6 Exogonic acid, a free component of Brazhian jalap resin (not linked structurally to its resin glycosides) exists as epimeric equilibrium of two major stereoisomers shown structurally together with two minor stereoisomers (2R,5S,7R / ,Z and 2R,5RJR / Z,E not shown)...

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