IV-hydroxy amino acids

Microsomal membranes containing L-amino acid iV-monooxygenase, iV-hydroxy amino acid dehydrogenase (oxy-dative decarboxylat-ing), aldoxime dehydratase, nitrile monooxygenase (D 9.3)... 

L-Amino acid iV-monooxygenase 2 iV-hydroxy amino acid dehydrogenase (oxydative decarbo-xylating) 3 aldoxime dehydratase 4 nitrile monooxygenase 5 glucosyltransferase... 

L-a-Amino acids have been prepared by the resolution of racemic a-amino acid amide by the L-specific aminopeptidase from Pseudomonas putida ATCC 12633 [7]. Enzyme from R putida ATCC 12633 cannot be used to resolve a-alkyl-substituted amino acid amides 103. Aminoamidase from Mycobacterium neoaurum ATCC 25795 has been used in the preparation of L-a-alkyl amino acid 104 (Fig. 34) and D-amide of a-alkyl-substituted amino acids by enzjmaatic resolution process using racemic a-alkyl amino acid amide as a substrate [169,179]. Amidase from Ochrobactrum anthropi catalyzed the resolution of a,a-disubsituted amino acids, iV-hydroxy amino acids, and a-hydroxy acid amides. The resolution process could lead to the production of chiral amino acids or amides in 50% yield. Recently, amino acid racemases have been used to get 100% yield of chiral amino acids [179]. 

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