Italian researchers synthesis

Recently, Italian researchers have developed a new procedure for the synthesis of five-membered cyclic nitronates with the use of enantiomerically pure epoxides (65-67) and aziridines (68) as the starting substrates (15) (Scheme 3.18, see also substrate B in Scheme 3.11, Eq. 1). 

During the same study, the Italian researchers aiming at the synthesis of carbaoctanose compounds (vide infra), synthesized a nine-carbon long intermediate 308 which served both to access the octanose and the septanose targets. As shown in Scheme 50, the route to 308 entailed vinylogous aldol coupling between pyrrole 76 and D-arabinose derived aldehyde 306 producing lactam 307, the immediate precursor of 308. To... 

Saverio Russo is a senior professor of industrial chemistry at Genoa University, Italy. He has been, and still is, project leader of several research programs supported by the European Union, Italian Ministry of University, and Chemical Companies. He has been working for more than 40 yeare in the field of macromolecular science and technology, mainly on advanced polymeric materials synthesis, characterization and applications. Polyamide 6 by the anionic routes has been one of the major topics of his research. He is author of more than 250 scientific publications, mostly in international journals, and six patents. Prof Russo has been member of the Scientific Committee of INSTM (Interuniversity Consortium of Materiab Science and Technology) and director of its S Hon on Functional and Structural Polymeric Materials. He was the co- itor of four volumes of Comprehensive Polymer Science, Peigamon, 1989 and two supplement volumes (1992 and 1996). He was the organizer and co-chairman of two lUPAC Symposia of Free Radical Polymerization Kinetics and Mechanism, in 1987 and 1996. 

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