Isovaleryl chloride

Isopropylidone acetone, m3 70 Isopropyl myristate, il31 Isovaleryl chloride, ml86... 

Cyclization of 2-aminonicotinic acid with butyric anhydride gave the 2-propyM//-pyrido[2,3-4 [l,3]oxazin-4-one 698 <2004W02004039774>, while the 2-isobutyl analogue 699 was prepared via the cyclization of amide 697, obtained from acylation of 2-aminonicotinic acid with isovaleryl chloride, in AC2O at 120°C <2003W02003103575>. 

Isovaleryl chloride (3-methylbutanoyl chloride). Use 34 g (0.4 mol) of isovaleric acid and 47 g (0.5 mol) of thionyl chloride. Proceed as for hexanoyl chloride the yield of isovaleryl chloride is 36 g (76%), b.p. 114-115°C, after distillation through a Vigreux column. 

Furthermore, the treatment of the same bithienyl synthon with 2-butyn-l-ol, copper iodide and Pd(PPh3)4 gave the corresponding bithiophene 135. The reduction with NaBH4 and the treatment of the resulting diol 136 with isovaleryl chloride gave a natural bithiophene 137 isolated from Eclipta erecta (87JOC5243). 

Isovaleric acid, dry, 20, 106 Isovaleric acid monohydrate, 20, 106 Isovaleryl chloride, 24, 21... 

Zinc di-isobutyl is a liquid, B.pt. 165° to IGT Tl., less readily oxidised than zinc dipropyl. It reacts vigorously with trihalides of phosphorus and arsenic, yielding corresponding phosphines and arsines. With acetaldehyde it forms principally ethyl alcohol, but also a little isobutyl alcohol, and with isovaleryl chloride it gives di-isobutyl ketone. ... 

Aliphatic acid chlorides (Cj to C ) can be prepared in 80-90% yield by mixing the acid with excess benzoyl chloride and distilling the volatile RCOCl. Other examples acrylyl chloride (70%)," propionyl chloride (80%), isovaleryl chloride."... 

Conversion of the blastmycinolactol diastereomers to the corresponding blastmycinones should be achievable by acylation of the free hydroxy group with isovaleryl chloride, as shown in Scheme 77 (Section 1.5.1). 

The direct reaction of 2-trimethylsilylmethyl-1,3-butadiene with isovaleraldehyde gives ( )-ipsenol (2-methyl-6-methylene-7-octen-4-ol) in rather low yield (30%) (eq 5). However, ipsenol is obtained in 62% overall yield by the reaction of 2-trimethylsilylmethyl-1,3-butadiene with isovaleryl chloride, followed by reduction with diisobutylaluminum hydride (eq 7). Similarly, ( )-ipsdienol (2-methyl-6-methylene-2,7-octadien-4-ol) is obtained by reduction of myrcenone, prepared by the reaction of 2-trimethylsilylmethyl-1,3-butadiene with 3,3-dimethylacryloyl chloride, in 75% overall yield (eq 8). 

Also obtained by Friedel-Crafts acylation of p-hydroxy-acetophenone with isovaleryl chloride (4 mol) in tetrachloroethane at 130° for 4 h (37%) [5626]. 

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