Isotopically labelled phosgene

The CAS registry numbers for isotopically-labelled phosgene are given in Appendix A3. 

The following is a selective list of some typical suppliers (USA and Western Europe) who are currently, or who have recently, produced research quantities of phosgene, isotopically-labelled phosgene, carbonyl difluoride or carbonyl chloride fluoride, for laboratory research or small-scale development studies. This list is always in a state of flux, but it is hoped that it will at least provide some useful starting points in the search for a supplier. Convenient laboratory syntheses of these materials are give in Appendix A5. 

The proposed mechanism for phosgene formation from CHCI3 is illustrated in Fig. 2.3 [1316,1631,1635] and this has been confirmed by isotope labelling techniques [1631]. Similarly, mechanisms for the formation of phosgene from CCl have also been described [1317,1637,1846], and these are summarized in Fig. 2.4. 

Phosgene is a versatile reagent for the isotopic labelling of organic molecules and its use for the preparation of a variety of radiopharmaceuticals is well established (see Section 10.8). Given the vast range of organic compounds which can be prepared from... 

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