Isopropyl methylphosphonic acid IMPA

Diisopropyl methylphosphonate is rapidly absorbed following oral administration in animals and is widely distributed throughout the body. Two metabolites of diisopropyl methylphosphonate are isopropyl methylphosphonic acid (IMPA) and methylphosphonic acid (MPA). Excretion of these metabolites in animals occurs primarily through the urine. 

EPA. 1992. Health advisory for isopropyl methylphosphonic acid (IMPA). U.S. Environmental Protection Agency, Office of the Assistant Administrator for Water. NTIS No. PB92-232149. 

Sarin is metabolized to isopropyl methylphosphonic acid (IMPA) and excreted by the kidneys (Little et al, 1986). Approximately 50% of soman is converted to free pina-colyl-methylphosphonic acid within 1 min in mice. The half-life of this metabohte is less than 1 h (Reynolds et al,... 

In addition, due to the reversibility of the binding reaction of sarin and soman to CarbE, it appears that CarbEs are involved in metabolic detoxification of these agents to their corresponding nontoxic metabolites isopropyl methylphosphonic acid (IMPA) and pinacolyl methylphosphonic acid (PMPA) (Jokanovic et al, 1996). 

Under acidic conditions, hydrogen fluoride (HF) and isopropyl methylphosphonic acid (IMPA) are formed which further hydrolyze to produce methylphosphonic acid (MPA) and isopropanol. Under alkahne condition, methylfluorophosphonic acid (MFPA) and isopropyl alcohol are initially formed which further hydrolyze to produce MPA and HF ... 

FIGURE 19.2 Hydrolysis pathway of sarin (GB), soman (GD), and cyclosarin (GIO hydrolysis pathway of nerve agents proceeds through the alkyl methylphosphonic acids, isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), and cyclohexyl methylphosphonic acid (CMPA) to methylphos-ponic acid (MPA). Analysis of the alkyl methylphosphonic acids allows identification of the parent agent, while assay of MPA is nonspecific. 

GB hydrolyzes first through the loss of fluoride, producing isopropyl methylphosphonic acid (IMPA) and hydrofluoric acid, and second, more slowly through the loss of the isopropanol to produce MPA (Rosenblatt et al, 1995 MacNaughton and Brewer, 1994 Kingery and... 

Isopropyl methylphosphonic acid (IMPA) C4H11PO3 1832-54-8 Hydrolysis of GB... 

Animal data indicate that nerve agents rapidly distribute to the brain, lungs, heart, diaphragm, kidneys, liver and plasma. The concentrations in all tissues initially decline rapidly, followed by a second more gradual decline, reflecting metabolism and urinary elimination, respectively. The measurement of the hydrolysis product of sarin [0-isopropyl methylphosphonic acid (IMPA)] in urine may be used for retrospective detection of exposure, although it is... 

Isopropyl methylphosphonic acid (IMPA) - Mutagenicity Salmonella, negative [45] No toxicity to rats fed 300 ppm in water for 90 d [45]... 

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