Nebulizers isopropanol

LC-PB-MS has been investigated as a potential confirmatory method for the determination of malachite green in incurred catfish tissue (81) and of cephapirin, furosemide, and methylene blue in milk, kidney, and muscle tissue, respectively (82). Results showed that the mobile-phase composition, nebulization-de-solvation, and source temperature all play an important role in the sensitivity of the method. The sensitivity increases with decreasing heat capacity of the mobile phase in the order methanol acetonitrile isopropanol water and with decreasing flow rate. A comparison of the PB with the thermospray interface showed that less structural information was provided by the latter, whereas the sensitivity was generally lower with the thermospray interface. 

Aerosol Generator. The atomizer shown in Figure 7 was designed to produce aerosols of certain organic materials that are soluble only in easily vaporized solvents such as isopropanol or toluene. Difficulties were encountered when using other nebulizers because of continual concentration of the solution resulting from evaporation of the solvent, making it impossible to predict or control the test air concentration and the particle size. 

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