Isoprenoid-substituted flavonoids

Isoprenoid-substituted flavonoids from Artocarpus (Moraceae) plants 98H(47)1179. 

Fukai, T., Nishizawa, J., and Nomura, T., Five isoprenoid-substituted flavonoids from Glycyr-rhiza eurycarpa, Phytochemistry, 35, 515, 1994. 

Llano, Y. et al., Constituents of the Moraceae plants. 25. Paratocarpins F-L, seven new isoprenoid substituted flavonoids from Paratocarpus venenosa Zoll., Pleterocycles, 41, 2313, 1995. 

Nomura, T., Hano, Y., and Aida, M., Isoprenoid-substituted flavonoids from Artocarpus plants (Moraceae), Pleterocycles, 47, 1179, 1998. 

Fukai, T. et al.. Four isoprenoid-substituted flavonoids from Glycyrrhiza aspera. Phytochemistry, 36, 233, 1994. 

Enzyme kinetic studies of inhibitor are very important for considering as a therapeutic agent. It is interesting to note that isoprenoid-substituted flavonoids having non-steroidal structures are potent un-competitive inhibitors of 5a-reductase. So, it would be expected that the isoprenoid-substituted flavonoid derivative would be an interesting lead compounds for testosterone 5a-reductase inhibitor. 

This licorice is the main species in Xinjiang licorice and is used as a crude drug in China (79). In our study of a commercially available Xinjiang licorice, the crude drug consisted of G. inflata (50%), G. eurycarpa (7.5%), G. uralensis (2.5%) and some unidentified material (40%) that may represent hybrids 294). About sixty phenolic compounds have been isolated. The main phenols in the roots of G. inflata are liquiritin (110, 0.2-0.6%) and isoliqiritin (109, 0.1-0.5%) (36), and the main isoprenoid-substituted flavonoids are licochalcone A (213, 0.12%) and glabrone (128, 0.065%) (295). 

Fukai, T, J. Nishizawa, M. Yokoyama, and T. Nomura Phenolic Constituents of Glycyrrhiza Species. 13. Five New Isoprenoid-Substituted Flavonoids, Kanzonols F-J, from Glycyrrhiza uralensis. Heterocycles, 36, 2565 (1993). 

Zeng, L., T. Fukai, T. Nomura, R.-Y. Zhang, and Z.-C. Lou Phenolic Constituents of Glycyrrhiza Species. 9. Five New Isoprenoid-Substituted Flavonoids, Glyasperins F, G, H, I, and J from the Roots of Glycyrrhiza aspera. Heterocycles, 34,1813 (1992). 

Sakagami, H., Jiang, Y, Kusama, K. et al. (2000). Induction of apoptosis by flavones, flavonols (3-hydroxyflavones) and isoprenoid-substituted flavonoids in human oral tumor cell fines. 

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