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Isoprenoid biosynthetic pathway chemical studies

This study provides evidence that Rab prenylation is important to statin-induced muscle toxicity, and that it is possible to identify suppressive small molecules that should not inhibit the beneficial effects of statins on blood cholesterol levels. The use of small molecules to dissect biosynthetic pathways is certainly not new, but affords a precise and rapid understanding of the phenotypic consequences of cellular perturbations. For the future, modern chemical biology techniques, including affinity labeling of isoprenoids [11], provide an attractive opportunity to identify the specific Rabs responsible for statin-induced muscle toxicity. As a common laboratory tool compound, G66976 is unlikely to become a clinical candidate. [Pg.161]


See other pages where Isoprenoid biosynthetic pathway chemical studies is mentioned: [Pg.255]    [Pg.255]    [Pg.345]    [Pg.210]    [Pg.72]    [Pg.533]    [Pg.533]    [Pg.232]   
See also in sourсe #XX -- [ Pg.281 ]




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