Isophane insulins biphasic

Biphasic insulins are fixed dose combinations of a short-acting and intermediate-acting insulin in various proportions. Examples are Humulin, a biosynthetic human insulin (rDNA origin) suspension with respectively 20%, 30% and 40% regular and 80%, 70% and 60% isophane insulin and Mixtard, a biphasic biosynthetic human insulin suspension with respectively 10%, 20% and 40% soluble and 90%, 80% and 60% isophane insulin. 

The new, short-acting insulins can be bound to protamine, allowing the preparation of mixed formulations. In an open, randomized, single-dose, three-way, crossover trial biphasic insulin aspart 30 (30% aspart plus 70% protaminated aspart, BIAsp 30), biphasic insulin lispro 25 (25% lispro plus 75% protaminated lispro, Mix 25), and biphasic human insulin 30 (30% regular plus 70% isophane insulin, BHI 30) were compared in 45 patients (15). Biphasic insulin aspart improved postprandial control better. There were 23 episodes of hypoglycemia with BIAsp 30, 19 with Mix 25, and 11 with BHI 30 two episodes with BIAsp 30, five with Mix 25, and two with BHI 30 required third-party intervention. 

A mixture of soluble and isophane insulins, officially called biphasic insulins. The shortacting analogue insulins are now also available in mixtures. Other nrixtures are available, but infrequently used. 

Biphasic insulins are, with one exception, proprietary mixtures of soluble (neutral) insulin and isophane insulin, which provide soluble (neutral) insulin at concentrations between 10% and 50% of the total insulin concentration. Human, porcine and beef are available, but most preparations in this group are of human insulin. These preparations remove the need for patients to mix soluble and isophane insulins, without... 

UK biphasic porcine insulin insulin Pork Mixtard 30 Porcine neutral and isophane insulin Diabetes... 

Compatibility. Soluble insulin may be mixed in the syringe with insulin zinc suspensions (amorphous, crystalline) and with isophane and mixed (biphasic) insulin, and used at once but there are insulins in which protamine is used as a carrier, and spare protamine will bind some of the short-acting neutral insulin, thus blunting its effects. 

If it is decided to give the patient orrly one injection per day, then 10-14 units of an intermediate-acting isophane suspension may be given. Dose increments (4 units) may be made on alternate days. Soluble insulin (neutral) may be added, or mixed (biphasic) insulins may be used, according to the patient s response. 

USA biphasic human insulin insulin Humulin M Humulin 50/50, 70/30, Ml, M2, M3, M4, M5 A mixture of isophane and soluble recombinant human insulin obtained from an E. coli expression system Diabetes... 

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