Insulin lispro biphasic

The new, short-acting insulins can be bound to protamine, allowing the preparation of mixed formulations. In an open, randomized, single-dose, three-way, crossover trial biphasic insulin aspart 30 (30% aspart plus 70% protaminated aspart, BIAsp 30), biphasic insulin lispro 25 (25% lispro plus 75% protaminated lispro, Mix 25), and biphasic human insulin 30 (30% regular plus 70% isophane insulin, BHI 30) were compared in 45 patients (15). Biphasic insulin aspart improved postprandial control better. There were 23 episodes of hypoglycemia with BIAsp 30, 19 with Mix 25, and 11 with BHI 30 two episodes with BIAsp 30, five with Mix 25, and two with BHI 30 required third-party intervention. 

Hermansen K, Colombo M, Storgaard H, O Stergaard A, Kolendorf K, Madsbad S. Improved postprandial glycemic control with biphasic insulin aspart relative to biphasic insulin lispro and biphasic human insulin in patients with type 2 diabetes. Diabetes Care 2002 25(5) 883-8. 

USA biphasic insulin lispro insulin Humalog MIX Recombinant human insulin where the B chain amino acids at 28 and 29 are inverted with different proportions of a protamine suspension Diabetes... 

BWP) 1670 BioTropin 14, 476 Biphasic human insulin 469 Biphasic insulin aspart 470 Biphasic insulin lispro 469 Biphasic porcine insulin 471 Bispecific T cell engager 1175 BiSphere 1305 BiSteel 871 Bitistatin 1283 Bivalent ligand binding 396 Bivalrudin 461... 

Biphasic insulin Lispro (a) 25% insulin Lispro/75% insulin Lispro protamine, (b) 50% insulin Lispro/ 50% insulin Lispro protamine. 

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