Isonitrile complexes technetium

Isomer shift data, Fe,S4 clusters, 38 20, 50 Isomorphic substitution, 39 179, 186 p-Isonicotinamide complexes, osmium, 37 307 p-lsonicotinamidepoly(proline) complexes, osmium, 37 307 Isonitrile complexes osmium, 37 245 technetium(I), 41 13-14 technetium(II), 41 31 technetium(IIl), 41 45 Isopolymolybdates, 19 239ff 19 265-280 crystallization from aqueous solution, 19 265-269... 

The chemistry of technetium is quite complex especially because of its numerous oxidation states (4-7 to -1). In the higher oxidations states (Tc(IV) to Tc(VII)), the metal behaves as a hard Lewis acid and its chemistry is dominated by multiple-bonded oxo ligands. The lower oxidation states ions can be classified as soft metals and will form stable compounds with hgands containing the following donor atoms P, As, S, Se, X (except F ), N, and itt-acceptors such as CO, NO, and isonitriles. 

Davison and coworkers have extensively studied technetium compounds that have potential application in nuclear medicine. In this process, significant advances in the isonitrile chemistry of technetium have been achieved. The type of complex of greatest current interest has the basic formula... 

Technetium is stabilized at low oxidation states by suitable ligands such as phosphines, isonitriles, carbon monoxide, and thiourea (Gorski and Koch 1970). Organometallic carbonyl (CO) complexes are interesting precursors for a new class of Tc(I) radiopharmaceuticals (Alberto et al. 2001 Schibli et al. 2000). 

Jones AG, Dionauge GF, Davison A et al (1985) Biological distribution and structure function relationship of hexakis isonitrile Tc(I) complexes (abstract). J Nucl Med All Sci 29 200 Jurisson S, Dancey K, McPartlin M, Tasker P, Deutsch E (1984) Synthesis, characterization, and electrochemical properties of technetium complexes containing both tetradentate Schiff base ligands and monodentate tertiary phopshine ligands single crystal structure of trans-(JV,2V-ethy-lene bis(acetylacetone-iminato)bis(triphenylphos- phine)-technetium(III)-hexafluoro-phosphate. Inorg Chem 23 4743-4744... 

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