Isoniazid Propranolol

Drugs that may affect benzodiazepines include alcohol, antacids, barbiturates, cimetidine, disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, oral contraceptives, narcotics, probenecid, propoxyphene, propranolol, ranitidine, rifampin, scopolamine, theophylline, and valproic acid. 

Antacids Isoniazid, phenytoin, propranolol and Decreased rate of... 

Santoso B. Impairment of isoniazid clearance by propranolol. Int J Clin Pharmacol Ther Toxicol 1985 23(3) 134-6. 

Clinically important, potentially hazardous interactions with albuterol, alcohol, clonidine, corticosteroids, danazol, diuretics, epinephrine, estrogens, isoniazid, lithium, oral contraceptives, pentamidine, phenothiazines, propranolol, somatropin, terbutaline, thyroid... 

Cerebellar symptoms such as tremor can be troubling and difficult to control. Medications that may be helpful include propranolol, primidone, and isoniazid. 

Cronqvist, J. Nilsson-Ehle, I. Determination of acyclovir in human serum hy hi -performance liquid chromatography. J.Liq.Chromatogr., 1988, 11, 2593-2601 [serum non-interfering acetaminophen, allopurinol, baclofen, carbacholine, cefuroxime, chlorpropamide, cilastatin, cloxacillin, diazepam, di-cumarol, digoxin, flucloxacillm, furosemide, fusidic acid, fusidic, glipizide, heparin, hydrochlorothiazide, imipenem, insulin, isoniazid, ketoprofen, metronidazole, naproxen, perphenazine, phenytoin, prednisolone, propranolol, p3razinamide, p3ridoxine, ranitidine, rifampicin, rifampin, spironolactone, streptomycin, sulfamethoxazole, trimethoprim, warfarin]... 

Propranolol causes a small reduction in the clearance of isoniazid, which seems unUkely to be of much practical importance. 

The clearance of a single 600-mg intravenous dose of isoniazid was reduced by 21%, from 16.4 to 13 L/hour, in 6 healthy subjects after they took propranolol 40 mg three times daily for 3 days. It is suggested that propranolol reduces the clearance of isoniazid by inhibiting its metabolism (acetylation) by the liver. However, as the increase in isoniazid levels is likely to be only modest this interaction is probably of little clinical importance. 

A group of patients taking enzyme inhibitors (cimetidine, dox-epin, isoniazid, nortriptyline, propranolol) had a tiotixene clearance of 9.51 L/minute, which was 71% less than that seen in patients taking tiotixene alone. It seems possible that the tiotixene dose will need to be reduced in those taking these drugs but this needs confirmation. Monitor concurrent use for tiotixene adverse effects and adjust the dose accordingly. 

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