Isoflavone aglycones

Soy isoflavone aglycones are asborbed faster and in higher amoimts than their... 

Satterfield, M., Black, D.M., and Brodbelt, J.S., Detection of the isoflavone aglycones genistein and daidzein in urine using solid-phase microextraction-high-performance liquid chromatography-electrospray ionization mass spectrometry, J. Chromatogr. B, 759, 33, 2001. 

Izumi, T., Piskula, M.K., Osawa, S., Obata, A., Tobe, K., Saito, M., Kataoka, S., Kubota, Y., and Kikuchi, M., Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans, J. Nutr., 130, 1695, 2000. 

Wiseman H, Casey K, Clarke DB, Barnes KA, Bowey E. Isoflavone aglycone and glucoconjugate content of high- and low-soy U.K. foods used in nutritional studies. J. Agric. Food Chem. 50,1404— 1410, 2002. 

Diffusion of aglycone Into blood. Small amounts of Isoflavone aglycones and larger amounts of galloylated catechins are found In plasma, suggesting that some aglycone diffuses across the basolateral membrane Into the blood. 

Isoflavonoids are also compounds that should be bom in mind for future cytotoxic studies with flavonoids. Isoflavones (aglycones with a 2-3 double bound, a 4 oxo group and the B-ring at C3 position) with the association of substituents mentioned above are not studied and could be. Besides, rotenoids are very cytotoxic isoflavonoids that are not well studied although one of them, 12a 3-hydroxyamorphigenin, is the most cytotoxic flavonoid found in our review, with values of less than 0.001 pg/mL on the six human cancer cell lines tested by Li et a/. [78]. 

F. Kuhn, M. Oehme, F. Romero, E. Abou-Mansour, R. Tabacchi, Differentiation of isomeric flavone/isoflavone aglycones by ion trap MS and a double neutral loss of CO, Rapid Commun. Mass Spectrom., 17 (2003) 1941. 

A study of miso found a particular rich mix of isoflavone aglycones, notably genestein and daidzdn, both known to be anticancer agents derived from their isoflavone precursors, genestin and daidzin. 

Figure 8.1 A diagram t)T ihc chemical structures of the isoflavone aglycones found in soybean as well as conjugates of daidzein. Similar conjugates arc fornicd of genistein and glycitein.

Table 18.9 Formation of isoflavone aglycons daidzein and genistein in SSF soya (mg/kg dry matter)...

Although the study did not aim to elucidate the mechanism of action, it was suggested that isoflavone aglycons are associated with the expression of human hpid metabolism genes. 

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