Aglycones diffusion

It Is assumed that most aglycones diffuse Into enterocytes. However, the partition coefficients of flavonolds vary widely depending on the structure, so It would be predicted that each flavonold would diffuse at different rates. 

Diffusion of aglycone Into blood. Small amounts of Isoflavone aglycones and larger amounts of galloylated catechins are found In plasma, suggesting that some aglycone diffuses across the basolateral membrane Into the blood. 

Phloretin is the aglycon of phlorizin and inhibits the facilitated diffusion of glucose catalyzed by GLUT1 or GLUT4. It has been used to terminate the uptake of glucose in timed assays with isolated membranes or reconstituted transporters. 

Dilute solutions in aqueous buffers exposed to diffused or direct sunlight gave dimethylamine and 5-diazoimidazole-4-carboxamide (215). At pH 1.0 or pH 7.4 and above, this cyclized to 2-azahypoxanthine (216). In the intermediate pH range, a different product was obtained (217) which happens to be the aglycone of the antibiotic bredinin. Compound (217) was not formed by irradiation of (216). It was suggested that the betaine arose from a carbene (218) which had been quenched by water. However, (217) is colourless. Formulated injection solutions which had been found to lose activity contained 10 mg/ml... 

Commelinaceae) shows an extra absorption band at 583 nm at pH values above 4.0, which makes this pigment highly colored at these pH values.The high stability of this type of pigments with as much as four acyl units was assumed to be due to the difficulty of water molecule diffusion to the hydrophobic center formed by the acyl groups and the aglycone. 

Uptake of released aglycone into colonocyte, probably by passive diffusion. 

Elavonoid transport from the sites of biogenesis or from the sites of transitional accumulation takes place by diffusion or active transport across the closely connected membranes of smooth EE and associated organelles (plastids, vacuoles, plasmalemma), and through the EB. During the endoplasmic transfer, the osmiophilic properties of the secretion disappear. This characteristic may be related to the possible bonding of aglycons with proteins, vjith terpenoids or with phenolic acids. 

Another possible mechanism may involve the hydrolyzation of anthocyanins by brush border enzymes such as lactase phloridzin hydrolase, prior to passive diffusion of the aglycone, as already proved for other flavonoids [74, 75]. 

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