Isocyanide-based multicomponent reactions

Domling, A. (2006) Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry. Chemical Reviews, 106, 17-89. 

An especially effective and fruitful way to synthesize heterocycles is by isocyanide-based multicomponent reaction (MCR).i... 

Domling A (2006) Recent developments In isocyanide based multicomponent reactions in applied chemistry. Chem Rev 106 17-89... 

Akritopoulou-Zanze I (2008) Isocyanide-based multicomponent reactions in drug discovery. Curr Opin Chem Biol 12 324—331... 

Hulme C, Nlxey T, Bienayme H, Chenera B, Jones W, Tempest P, Smith AL (2003) Library generation via postcondensation modifications of isocyanide-based multicomponent reactions. Meth Enzymol 369 469 96... 

Banfi L, Basso A, Riva R (2010) Coupling isocyanide-based multicomponent reactions with ahphatic or acyl nucleophilic substitution processes. Synlett 23-41... 

The imidazo[l,2-a]quinoxaline scaffold 233 was developed by Krasavin et al. via two isocyanide-based multicomponent reactions sequentially introducing four diversity elements to the final products [70]. The first step involves the synthesis of quinoxaUnes 237 from o-phenylenediamines 234 and followed by the Groebke-Blackbum-Bienayme multicomponent reaction (Scheme 43). The described methodology provides a tool to constmct the medicinally relevant heterocycles. 

Fig. 2 The Passerini and Ugi reaction, the most prominent examples of the isocyanide-based multicomponent reactions...

Library Generation via Postcondensation Modifications of Isocyanide-Based Multicomponent Reactions... 

Several groups have pioneered the use of such multicomponent condensation reaction (MCR) technologies, including those led by Ugi, Bienayme, Domling, and Weber, spawning new chemically driven companies that have rapidly built up their own internal corporate collections. One particular branch of MCR methodologies, namely postcondensation modifications (or secondary reactions) of IMCRs (isocyanide - based multicomponent reactions), forms the basis of this chapter. 

In summary, isocyanide-based multicomponent reactions and subsequent secondary reactions have experienced a resurgence of interest in the past decade and appear well positioned for growth as we enter the new millenium. 

Pyrane derivatives were obtained through a stereoselective isocyanide-based multicomponent reaction. The reaction between an isocyanide, a dialkyl acetylene-... 

A limitation of isocyanide-based multicomponent reactions lies in the small number of available isocyanides. The problem can be solved by transformation of a single isocyanide into many other isocyanides, as reported by Bossio et al. [65],... 

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