Isocupressic acid

Figure 2.16 Three labdane resin acid compounds (a) isocupressic acid, (b) the acetyl derivative acetlisocupressic, and (c) the succinyl derivative succinylisocupressic, found in certain pine, juniper and cypress trees and which are abortifacient in late-term pregnant cattle.

Gardner, D.R. and James, F.F. (1999). Pine needle abortion in cattle Analysis of isocupressic acid in North American Gymnosperms, Phytochem. Anal., 10, 1-5. 

Gardner, D.R., Molyneux, R.J., James, F.F., Panter, K.E. and Stegelmeier, B.L. (1994). Ponderosa pine needle-induced abortion in beef cattle Identification of isocupressic acid as the principal active compound, /. Agric. Food Chem., 42, 756-761. 

Labdanes of the series of gomojosidae, isolated from the leaves of Viburnum suspensum (Caprifoliaceae) exhibited antibacterial activity against E.coli, Aeromonas salmonishida and B. subtillis [102]. Cryptotrienolic and isocupressic acid isolated from the bark of Juniperus procera were found to exhibit weak antibacterial activity when tested against B. subtillis, S. aureus, Str. durans, E. faecilis, and Mycobacterium... 

The isocupressic acid (16.9) in the needles of Pinuspon derosa can cause abortions in catde that eat the needles.52 This may be a possible lead for new abortifacients for humans. 

Corymbol deriv., T36.2 Isocupressic acid, T34.10 Beyerol, T35.5 Sideritol, T 12.11 Grindelic acid, T 14.3 Leucoxol, T"32.4 Sueveolic acid, T"32.11 Asperdiol, T"31.4 C20H32O4... 

Gardner, D. R., Molyneux, R. J., James, L. R, Panter, K. E., and Stegelmeir, B. L. 1994. Ponderosa Pine Needle-Induced Abortion in Beef Cattle Identification of Isocupressic Acid as the Principal Active Compound. Journal of Agricultural and Food Chemistry 42 756-761. 

Other related diterpenes of some interest, the hydroxylation of which by microbial methods has recently been described, are isocupressic acid [69], dehydroabietic acid derivatives [70,71], grindelane derivatives [72-75], kolavenol acetate [76], norambreinolide... 

Methyl-corypalline Methyl eugenol Methyl isobutyl ketone Methyl isocupressate Methyl-l-propenyl disulfide Methyl-laurate Methyl-n-amyl ketone Methyl n-nonyl ketone Methyl nigakinone Methyl palmitate Methyl-pelletierine Methyl salicylate Methyl-swertianin Methylacetic acid Methylanthranilate Methylchavicol Methylcytisine... 

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