Linezolid Isocarboxazid

Clinically important, potentially hazardous interactions with amprenavir, clonidine, ephedra, epinephrine, eucalyptus, guanethidine, iobenguane, isocarboxazid, linezolid, MAO inhibitors, paroxetine, phenelzine, quinolones, sparfloxacin, St John s wort, tranylcypromine... 

Clinically important, potentially hazardous interactions with alprazolam, amphetamines, astemizole, clarithromycin, clozapine, desipramine, dexibuprofen, dextroamphetamine, diethylpropion, droperidol, duloxetine, erythromycin, haloperidol, imipramine, isocarboxazid, linezolid, lithium, MAO inhibitors, mazindol, meperidine, methamphetamine, midazolam, moclobemide, nortriptyline, phendimetrazine, phenelzine, phentermine, phenylpropanolamine, phenytoin, pimozide, pseudoephedrine, selegiline, serotonin agonists, sibutramine, St John s wort, sumatriptan, sympathomimetics, tramadol, tranylcypromine, trazodone, tricyclic antidepressants, troleandomycin, tryptophan, zolmitriptan... 

Clinically important, potentially hazardous interactions with acyclovir, alcohol, amphetamines, barbiturates, CNS depressants, fluoxetine, furazolidone, general anesthetics, glycopyrrolate, glycopyrronium, isocarboxazid, linezolid, lithium, MAO inhibitors, moclobemide, phenelzine, phenobarbital, phenothiazines, rasagiline, ritonavir, selegiline, sibutramine, SSRIs, tranquilizers, tranylcypromine, tricyclic antidepressants, val acyclovir... 

The UK manufacturer contraindicates the concurrent use of linezolid with or within 2 weeks of taking any other drug that inhibits MAO-A or MAO-B. They specifically name the non-selective MAOIs isocarboxazid and phenelzine, the RIMA, moclobemide, and the MAO-B inhibitor, selegiline. Linezolid has reversible non-selective MAO-inhibitory activity, and this warning is based on the sometimes serious reactions that have occurred when non-selective MAOIs are given sequentially (see MAOIs + MAOIs or RIMAs , p.1137) or MAOIs are given with MAO-B inhibitors, see MAO-B inhibitors + MAOIs or RIMAs , p.692. 

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