4-Isobutylphenylacetic acid

C12H1405 trans-2,3,4-trimethoxycinnamic acid 33130-03-9 25.00 1.2132 2 24235 C12H1602 4-isobutylphenylacetic acid 1553-60-2 20.00 To 2... 

Isobutylphenylacetic acid (ibufenac, Dytransin), / -Mc2-GH GHg GgH4 GHj GO OH, possesses anti-inflammatory and analgesic activities 2-4 times those of acetylsalicylic acid measured by an ultra-violet erythema test and by the method of Randall and Sellito, and antipyretic properties 4 times those of acetylsalicylic acid. In a dose of 960 mg it is effective in delaying the development of ihurfyl nicotinate erythema in man . 

Synthesis (Mayer and Testa, 1997 Cleij et al., 1999 Kleemann et al., 1999) a) Treatment of ethyl 4-isobutylphenylacetate and diethyl carbonate with sodium ethoxide gives diethyl 4-isobutylphenylmalonate, which is methylated using methyl iodide and sodium ethoxide. Saponification followed by decarboxylation of the resulting malonic acid derivative affords ibuprofen. 

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