Antidepressants irritable bowel syndrome

Constipation may be caused by slow intestinal transition, pelvic floor dysfunction, bowel dysfunction like irritable Bowel syndrome and tumours, but can also be secondary to other diseases and life conditions. Many medicines cause constipation, for example opiates, calcium channel blockers and drugs with anticholinergic effects, e.g. antidepressants. 

Several organs are the target for the anticholinergic (anti-muscarinic) activity of the tricyclic antidepressants. They constitute the most common and troublesome adverse effects of the tricyclic antidepressants, but the peripheral anticholinergic actions can also be put to therapeutic use in conditions such as irritable bowel syndrome, premature ejaculation, and nocturnal enuresis. 

Tianeptine, (K5)-7-(3-chloro-6-methyl-6,ll-dihydrodibenzo[c/ [l,2]lhiazepin-ll-yl-amino)heptanoic acid 5, 5-dioxide, is an antidepressant effective against anxiety accompanying mood disorders. The drug is used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. The TLC method was used to separate the photodegradation products of tianeptine [16] (Figure 14.13). 

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