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Irradiation effects damage process

The p53 protein is central to a control function that imderlies progress in the cell cycle when DNA damage or other faults in the cell cycle are present. If cells are exposed to damage such as UV irradiation, an increase in the concentration of p53 protein is observed and the p53 protein is activated. One of the signals that has been identified as leading to activation of the p53 protein is a DNA strand break. Conditions that favor a strand break are the effect of UV irradiation, incomplete repair processes or a pause in DNA replication due to a damaged DNA template. [Pg.447]

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7-Irradiated processes

Damage effect

Damage process

Damaging Processes

Irradiation effects

Irradiation effects radiation damage process

Irradiation processes

Processing damage

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