Methyldopa Iron compounds

CENTRALLY ACTING ANTIHYPERTENSIVES IRON COMPOUNDS 1 antihypertensive effect of methyldopa Ferrous sulphate and possibly ferrous gluconate may chelate methyldopa in the intestine and 1 its absorption Monitor BP at least weekly until stable... [Pg.50]

Information is limited, but this interaetion appears to be established and clinically important. Monitor the effeets of eoneurrent use and increase the methyldopa dosage as neeessary. Separating the dosages by up to 2 hours apparently only partially reduees the effeets of this interaction. Ferrous gluconate appears to internet like ferrous sulfate, and all iron compounds would be expeeted to internet similarly. [Pg.897]

LEVODOPA, METHYLDOPA IRON-CONTAINING COMPOUNDS 1 plasma concentrations of methyldopa (peak levels 1 by 55%) and levodopa, with risk of therapeutic failure Iron preparations impair the absorption of methyldopa and levodopa Be aware and separate oral intake by at least 2 hours... [Pg.741]

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