Ir-Catalyzed Synthesis of Indole from 2-Aminoaryl Ethyl Alcohol

Ir-Catalyzed Synthesis of Indole from 2-Aminoaryl Ethyl Alcohol 

Ir Catalysts with Pyrazoyl and Pyrazoyl-1,2,3-bidentate (N-N) Ligands for the Synthesis of Tricyclic Indoles 

Messerle and coworkers reported that a cationic iridium(lll) complex with a methyl-bridged bipyrazoyl or pyrazoyl-l,2,3-triazole (N-N) ligand [lr(N-N)Cp Cl] B Ar 4 (B Ar .j = tetrakis[3,5-bis(trifluoromethyl)phenyl]borate) had catalytic activity for the synthesis of tricyclic indoles [161]. The process 

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Grigg and coworkers reported that the Ir-catalyzed synthesis of indoles from 2-aminoaryl ethyl alcohols [20]. In a typical example, 2-aminophenyl ethyl alcohol and a catalytic amount of [Cp IrCl2]2 (2.5mol%) were combined with KOH (2 e quiv.) at 110 ° C for 24 h to give 3-benzylindole in 78% yield with high selectivity (Scheme 11.13). 

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