Iopanoic acid excretion

Biliary excretion of contrast medium is affected by the bile flow (688, 734, 745, 777, 778). Bile is isosmotic with plasma and is produced from the transport of water from the liver cell into the bile canaliculi (canalicular bile flow) and from the excretion and reabsorption of water and electrolytes in the bile ductules (ductular bile flow). Bile flow is increased by taurocholate and dehydrocholate their presence in the canaliculi creates an osmotic gradient that produces the flow of water and solute. There is a positive correlation between the canalicular bile flow stimulated by taurocholate and the amount of iopanoic acid excreted by the liver. Feeding the patient a fatty meal or taurocholate at the time that iopanoic acid is administered can improve the quality of cholecystograms(734). 

Gall bladder Various oral cystographic agents, e.g., iopanoic acid Telepaque etc. Anion transport Urich K, Speck U (1991) Biliary excretion of contrast media. Progr Pharmacol Clin Pharmacol 8 307-322... 

Ethambutol had no effect on the urinary excretion of sodium or potassium and there was no clinical evidence of volume depletion in patients receiving this agent. The hyperuricemia of ethambutol was not reversed by salicylates in 3 patients in whom this was studied. Ethambutol did not inhibit the effect of probenecid, sulfinpyrazone or iopanoic acid in 3 additional patients. 

The fate of the cholecystographic agent iopanoic acid (mol. wt. 571) has been studied in cats, dogs, and man (McChesney and Hoppe, 1954). Iopanoic acid appears to be excreted in bile as its ester glueuronide, which has a molecular weight of 747. In cats, 18 hours after the intravenous... 

Pancreas Oral cholecysto-graphic agent iopanoate ( ) experimental Unknown excretion into pancreatic duct Schmiedl U etal (1994) Imaging of exocrine pancreatic function investigation of the bioavailability of weak organic acids as potential pancreatic contrast agents for computed tomography. Invest Radiol 29 689-694... 

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