Ionophores, fluoride

D and E appear to stimulate the formation of 0 directly. The ability of A 23187 to elicit formation of O from PMNs 24,59,60,68.70) appears to be due to its action as an ionophore for Ca (see below). Other active stimuli include fluoride, notable because its effect is reversible human leucocyte pyrogen which might have a function in vivo and phorbol myristate acetate The latter has been very useful as a potent stimulus of the burst in various studies of the kinetics and mechanism of activation of the burst. 

A similar approach is used for the design of novel fluoride ionophores The important characteristic of these ionophores is not only the very good selectivity, but also the exceptional stability over a period of 30 days, as shown in Figure 3.4.11. 

Figure 3.4.12 Fluoride- (right) and arsenate- (left) selective ionophores. (Adapted from references 36 and 37.)...

By now it is established that bidentate tin ionophores are the ideal generic substructure upon which ionophores for a specific anion can de designed.Based on this idea, selective ionophores, such as those shown in Figure 3.4.12, have been proposed for fluoride and arsenate. 

Oxygen uptake, O5, H2O2, OH production, as well as chemiluminescence, are stimulated by many agents, particulate or soluble, which include bacteria, latex, and zymosan (Table 4) (C6, B3), PMA (Jl, G6, R2), ionophores (W4), complement peptide Cg (G3), fluoride ion (G9, H2), and a chemotactic factor iV-formylmethionyl peptide (S5). These events have been demonstrated to be independent of phagocytosis and even of degranulation they only require contact of the stimulus with the cell membrane (M2, R4, G3, H2, G9). 

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