Ionization of proteins

Karas M and Hlllenkamp F 1988 Laser desorption Ionization of proteins with moleoular masses exoeedlng 10,000 Daltons Anal. Chem. 60 2299-301... 

M. Karas and F. Hillenkamp, Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons, Anal. Chem., 60, 2299 2301 (1988). 

Karas, M. Hillenkamp, F. Laser Desorption Ionization of Proteins With Molecular Masses Exceeding 10,000 Daltons. Anal. Chem. 1988, 60, 2299-2301. 

P23. Putzeys, P., and Bouckaert, L., The ionization of proteins, I. Mededeel. Koninkl. Vlaam. Acad. Wetenschap. Belg. 4, 3 (1942). 

Karas M, Hillenkamp F (1988) Laser desorption ionization of protein with molecular masses exceeding 10000 Daltons. Anal Chem 60 2299-2301. doi 10.1021/ac00171a028... 

Study of the ionization of protein groups by measuring the associated spectral changes is commonly called a spectrophotometric titration. Measurements of the (usually) smaller spectral perturbations induced by change of solvent are usually carried out by the difference spectral technique. We have examined both of these methods of study from an interpretative as well as an experimental point of view. 

Below, an overview of the ionization processes in ESI is provided. A detailed in-depth discussion of the ESI mechanisms is beyond the purpose and scope of this chapter. While most mechanistic discussions in ESI are focussed on the ionization of proteins, we try to focus on the ionization of small molecules. ESI-MS of proteins is discussed in Ch. 16.2.3. 

K. Linderstrom-Lang, Compt. Rend. Trav. Lab. Carlsberg, 15, 1 (1924). The Ionization of Proteins. C. Tanford and J. G. Kirkwood, /. Am. Chem. Soc., 79, 5333 (1957). Theory of Protein Titration Curves. I. General Equations for Impenetrable Spheres. 

Introduction of ionization of protein molecules by soft laser desorption, which is basic theory for MALDI-TOF MS and SELDI-TOF MS 1995 Definition of proteomics was first coined... 

Linderstrom-Lang, K. On the ionization of proteins. Compt. Rend. Trav. Lab. Carlsberg 1924, 15,... 

Karas, M. and Hillenkamp, F. (1988) Laser desorption ionization of proteins with molecular mass exceeding 10,000 Daltons. Ami. Chem. 60,2299-2301... 

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