Ionic liquid-supported oligosaccharide

Wang et al. [47] have reported a novel and efficient protocol for ionic liquid supported synthesis of oligosaccharides, which have biological and therapeutic importance. This methodology is remarkable for improved phase separation from organic solvent or aqueous phase. The ionic liquid supported oligosaccharides were... 

A promising technique for the tagged oligosaccharide synthesis that makes use of an ionic-liquid support has recently emerged.259 As with the polymer-supported and fluorous tag-supported syntheses, ionic liquid-supported assembly expedites oligosaccharide synthesis by eliminating the need for chromatographic purification of the intermediates. 

Considerable effort has been made in recent years to improve the yields of oligosaccharide synthesis. The selection of the appropriate functional resin is, in many cases, crucial to the outcome of oligosaccharide syntheses. Here, we briefly review the functional resins that have been used for oligosaccharide synthesis. The chapter is divided into two main sections First the most common insoluble and soluble resins applied in oligosaccharide synthesis are reviewed and then the different types of linkers applied in oligosaccharide synthesis are summerized. Two subsections are dedicated to ionic liquids (Section 20.3.3), representing a special case of soluble resins , and magnetic parhcles (Section 20.2.3), which are considered a relatively new concept of insoluble solid supports. 

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