Ion Chromatography in Clinical Chemistry

Due to the robustness and the high specificity of ion chromatography for fermentation monitoring as described above, its application in online mode is conceivable, as in many cases sample preparation is restricted to dilution and filtration. 

One of the most important applications of ion chromatography in clinical chemistry is the investigation of body fluids such as saliva, urine, and serum for inorganic and organic anions and cations. 

In this field, saliva [311] and teardrops [312] represent rather simple matrices and may be directly injected without any sample preparation after appropriate dilution with de-ionized water. As seen in the anion chromatogram of a human saliva sample (390 mg ad 25 mL H2O) in Fig. 9-204, the constituents may be separated without any interference. The detection of small quantities of bromide is remarkable. Its occurrence was unknown until now and the source cannot be explained at present. 

Bromide, the almost forgotten first antiepileptic, is again successfully used for epilepsy treatment, especially with patients for whom other antiepileptics do not show any effect [313]. Therefore, frequent control of the bromide level in the 

Under similar chromatographic conditions it is also possible to determine p-aminohippuric acid, which represents one of the control substances for diagnosing kidney function. On the basis of certain analytical values, it is possible 

---

Another apphcation of ion chromatography in clinical chemistry is the analysis of carbohydrates [352] in physiological samples, which is more and more often carried out with the HPAEC-PAD method. In light of this, the analysis of mannitol, 3-0-methylglucose, and lactulose described by Fleming et al. [353] is of great interest. Via urinary excretion, the concentration ratio of these three... 

---