Sensor ion-channel

Figure 19.9 Top Architectures of ion channel sensor materials M12, M13, and M14. Middle Scheme for protamine detection with M12 and [Fe(CN)6]3 probe. Bottom Scheme for heparin detection with the piotamine-M12 conjugate M13 and [Mo(CN)s]4 probe.

Umezawa Y Aoki H, Ion channel sensors based on artificial receptors, Anal. Chem., 2004,76,320A—326A. 

An extension of artificial membranes for ion selective electrochemical work was the construction of biomimetic ion channel sensors [65]. These devices were based on Langmuir-Blodgett deposition of charged lipid membranes onto a glassy carbon electrode. This work indicated that a conductive zone can be opened reversibly by a stimulant-membrane interaction by surface charge alterations. This work has demonstrated how the concept of the conductivity measurement could be extended to the more common and useful technique of cyclic voltammetry. 

Eisenbetg, Superlattices Microstruct., 34(3-6), 451—457 (2003). Silicon-based Ion Channel Sensor. 

In an attempt to mimic the highly sophisticated ion transport properties found in biological membranes for the development of an ion channel sensor, a comprehensive study on artificial systems was carried out [10]. It was shown that the permeability of orientated monolayers of various calixarene esters is strongly influenced by the complexation with metal ions [11]. It was reported that the membrane permeability of calix[6]arene esters for a neutral redox-active... 

Figure 6 An ion-channel sensor based on a PNA probe immobilized on gold electrode, and detection of the hybridization based on the elec- ...

ICSs have also been successfully employed for anion sensing. For instance, Umezawa et al. prepared an ion-channel sensor that is selective for phosphate ion in aqueous solution by surface functionalization of a gold electrode with a SAM of a bis-thiourea receptor. They studied the behavior of the material in the presence of several inorganic anions by cyclic voltammetry with [Fe(CN)g] as the redox marker. In the absence of anions, the surface... 

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