Iodination indirect labeling methods

The chemistry of iodine radionuclides used in nuclear medicine has been extensively explored. Isotopic exchange procedures, direct iodination approaches (those using chloramine-T and iodogen), and indirect approaches (the Bolton-Hunter method) are but a few of the well-known synthetic strategies to label biomolecules with iodine (24). Some of the most important 1-labeled imaging tracers [1-labeled iodoazomycin arabinoside ( lAZA), 1-labeled vasoactive intestinal peptide ( 1-VlP), etc.] will be discussed in the following sections. 

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