Investigational medicinal products supplies

All submissions need to include a completed application form and, prior to submitting the application, a reference number (EudraCT number) must be obtained [10]. In addition the applicant needs to supply additional documents (depending on the type of trial and investigational medicinal product), but normally including ... 

RO 1130830 (1, figure 1 below), currently under investigation for the treatment of osteoarthritis, is prepared on a multi-hundred-kilo scale in four steps from advanced intermediates supplied from commercial sources. Crucial to the success and timeliness of the scale-up was close collaboration between research, chemical development and scale-up, pilot plant production and commercial sourcing. Identification of key bond formation sites, reduction of the longest linear sequences and minimization of the number of isolations advanced evolution of the synthetic scheme from the initial medicinal chemistry route to a scaleable pilot plant process. 

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