Investigational labelling

Based on its nature (aqueous solutions, physiological conditions, well-investigated labeling, and staining reactions) and the historical transition from slab-gel electrophoresis to CE, the main targets are biological and bioequivalent samples such as proteins, peptides, polynucleotides, oligonucleotides, and carbohydrates. 

By investigating labeled methin-cyanine analogs v/e have found that the chemical shift of the signals show a quite similar dependence on the nature of the basic ring... 

The figure in Box 3-C shows a high-resolution separation of the soluble proteins of E. coli. The investigator labeled the proteins with -containing amino acids. 

The mechanistic routes to (15e) have been investigated. Labelling experiments revealed that the expelled methyl radical originates separately from C-2, C-3 and C-4 of the chroman ring by three competing pathways <70OMS(3)753). A similar observation has been made for... 

Labeling A mock-up or printed representation of the proposed labeling that will be provided to investigators in the proposed clinical trial should be submitted. Investigational labels must carry a caution statement as stated earlier. The required statement reads Caution New Drug—Limited by Federal (or United States) law to investigational use. ... 

Enzymes are currently the most widely used and investigated labels for immunoassays, because a single enzyme label can provide multiple copies of detectable species. This catalytic amplification results in immunoassay detection limits that rival those of radioimmunoassay without the storage and disposal problems associated with radioisotopes. Enzyme immunoassays label either ligands or antibodies with enzyme, and enzyme activity in bound or free fractions is measured. Heterogeneous immunoassays employing enzymatic labels have been named enzyme-linked immunosorbent assays (ELISAs). ELISA methods usually employ antibody immobilized onto the wells of polystyrene microtiter plates, and may be... 

Figure 2. Universal plot of all A — Ac data (x < 10) for the substances investigated. Labels V ana L designate vapor and liquid branches, respectively. For quantum substances (a> < —0.1), only vapor points are...

Alternatives to applying numbers directly to plastics objects have been investigated. Labels bearing the registration number may be tied to objects with holes or handles. However, labels can become separated or lost and are not visually pleasing when an object is to be displayed. Adhesive labels are insufficiently permanent and often leave a disfiguring adhesive residue (Figure 7.12). Soft 2B-4B pencils can be used to mark polyethylene and poly (vinyl chloride). 

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