Protein-based machines inverse temperature transitions

Consequences of Protein Machines Based on the Inverse Temperature Transitions... 

Due to the struggle to survive under circumstances of limited food supply, organisms evolve to use the most efficient mechanism available to their composition. The most efficient mechanism available to the proteins that sustain Life would seem to be the apolar-polar repulsive free energy of hydration as observed for the inverse temperature transitions for hydrophobic association. The efficiency of designed elastic-contractile protein-based machines and a number of additional properties make designed protein-based materials of substantial promise for the marketplace of the future. 

Figure 5.2. The four phase transitions of the model protein (GVGVP)2si in water over the temperature range from -20 to 120°C. The familiar transition of the melting of ice and the vaporization of water are shown with the relative magnitudes of the heats of these transitions to those of protein heat denaturation and to the innocuous looking inverse temperature transition near 30°C that we believe to be the basis of the function of protein-based machines of Life. See text for discussion.

This section categorizes consilient protein-based machines. In preparation for doing so, however, we seek out appropriate definitions with which to delineate the several different kinds of machines possible by means of inverse temperature transitions. 

Relative Magnitude of the Endothermic and Exothermic Components of the Inverse Temperature Transition and Relevance to Biology s Protein-based Machines... 

Biology s reversal of the much-noted arrow of time and equivalently biological evolution derive simply from fundamental reality of biosynthesis within the context of inverse temperature transitions as expressed in the hydrophobic consilient mechanism. The production of a new and improved protein-based machine occurs by chance, but most significantly it occurs at a cost in energy no greater than that required to produce the initial less useful protein-based machine. This is the nature of the biosynthesis of protein and of the other great macromolecules (the nucleic acids, DNA and RNA) of biology. 

Thus, from the perspective of the inverse temperature transition, evolution and natural selection become apparent consequences for protein-based machines that function by the hydrophobic and elastic consilient mechanisms. 

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